FOR PROFESSIONAL AESTHETIC MEDICAL USE ONLY  ·  CE-Marked  ·  Exporting to 40+ Countries
✦ Anti-Aging Perioral Rejuvenation · Medical-Grade Lip Filler

Vitamin B12 & HA — The Perfect Symphony for Lip Rejuvenation

A medical-grade lip filler designed for nonsurgical lip augmentation and perioral anti-aging. Vitamin B12 (cobalamin) stimulates collagen production and tissue regeneration, while fractionated-molecular-weight hyaluronic acid restores lip volume and hydration — addressing lip thinning, fine lines, and volume loss from aging.

CEHISHU combines nano-encapsulated Vitamin B12 filler technology with calibrated fractionated hyaluronic acid (2600KD–50KD) — nitrogen-stabilized without chemical cross-linking agents like BDDE. The result: collagen-stimulating lip volume restoration with reduced risk of adverse reactions, for clinics seeking a premium alternative to traditional HA-only dermal fillers.

20 mg/ml Fractionated HA
0.1% Vitamin B12 (Cobalamin)
2600–50 KD HA Molecular Weight Range
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CEHISHU Lip Filler Gel product
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Clinically Validated Documented before/after results
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40+ Export Markets

Europe, Americas, MENA, APAC

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CE-Marked

Medical device compliant

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GMP Manufacturing

ISO 13485 facility

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OEM / ODM Available

Private label partnerships

Anti-Aging Mechanism · How CEHISHU Works

Three Actions for Perioral Rejuvenation

A triple mechanism for nonsurgical lip augmentation and perioral anti-aging — deep hydration, collagen stimulation, and lip volume restoration, engineered specifically for the delicate lip mucosa and perioral region.

01

Hydrate

High-concentration fractionated hyaluronic acid (20mg/ml, 2600KD–50KD) restores extracellular matrix hydration, plumping thinning lips from within — the foundation of lip volume restoration.

→ 20 mg/ml fractionated HA · multi-layer hydration
02

Stimulate

Nano-encapsulated Vitamin B12 (cobalamin) combined with low-molecular-weight HA stimulates collagen production, DNA synthesis, and tissue regeneration — actively reversing lip aging at the cellular level.

→ Cobalamin · collagen stimulation · DNA synthesis
03

Define

The nitrogen-stabilized HA matrix provides lip contour definition and volume, restoring youthful lip projection without altering tissue structure — a true nonsurgical lip augmentation solution.

→ Nitrogen-stabilized HA matrix
Vitamin B12 cobalamin molecular structure for anti-aging dermal filler
Star Ingredient · Vitamin B12 (Cobalamin) for Anti-Aging

Why B12 Matters for Lip Rejuvenation & Collagen Stimulation

Vitamin B12, also known as cobalamin — which gives it its characteristic ruby red color — is a water-soluble vitamin that plays an integral role in DNA synthesis and acts as a cofactor in numerous biochemical processes. As a collagen-stimulating filler ingredient, B12 is uniquely valuable for perioral anti-aging.

In the context of lip mucosa, B12 nourishes and promotes repair of damaged nerve tissue, accelerates proliferation of granulation tissue, and stimulates epithelial cell regeneration — directly addressing the cellular causes of lip thinning and perioral aging.

  • ✓ Anti-inflammatory action — reduces inflammation, improving skin health and appearance
  • ✓ Collagen stimulation via DNA synthesis — improves wrinkles and signs of lip aging
  • ✓ Tissue regeneration — in-vivo testing confirms stimulation of collagen fiber repair
  • ✓ Analgesic & anti-pruritic — provides comfort during and after nonsurgical lip augmentation
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Clinical relevance: B12 deficiency is associated with dermatological conditions including acne, psoriasis, hyperpigmentation, atopic dermatitis, and vitiligo — underscoring cobalamin's essential role in skin health and anti-aging medicine.

Fractionated-Molecular-Weight Hyaluronic Acid · Non-Crosslinked

Nitrogen-Stabilized HA — Without BDDE Cross-Linking

For longer-lasting lip volume restoration, we use a mechanical process under nitrogen pressure to stabilize a blend of fractionated-molecular-weight hyaluronic acid — from 2600 KD down to 50 KD — without chemical cross-linking agents like BDDE.

This non-crosslinked HA filler approach yields a stable mixture with both hydrating and bio-restructuring capabilities — defining tissue volume without altering tissue structure, reducing the risk of nodules and hypersensitivity common with chemically cross-linked fillers.

  • ✓ No BDDE or chemical cross-linkers — reduced risk of adverse reactions
  • ✓ Multi-layer hydration — high MW (2600KD) for surface plumping, low MW (50KD) for deep tissue
  • ✓ Longer duration — nitrogen stabilization extends the anti-aging effect
  • ✓ Bio-restructuring — supports natural collagen architecture
HA and B12 skin science
Technical Specifications

Product Parameters

Precise, calibrated, and clinically documented — built for the professional aesthetic medicine setting.

Hyaluronic Acid Concentration20 mg/ml
Vitamin B12 Concentration0.1% (900 pg/ml)
HA Molecular Weight Range2600 KD – 50 KD (fractionated matrix)
Stabilization MethodMechanical process under nitrogen pressure — no chemical cross-linking
PresentationPre-filled syringe, 1 ml
Indication AreaLip mucosa and perioral region
Target Injection PlaneDermal-submucosal plane (per vascular anatomy)
Storage2–8°C, protect from light
Shelf Life24 months unopened
Clinical Evidence · Lip Filler Study Results

Documented Anti-Aging Before & After Results

Clinical study of CEHISHU B12 + HA lip filler demonstrates measurable lip volume restoration and perioral rejuvenation — quantified evidence for clinics evaluating nonsurgical lip augmentation options.

In controlled clinical evaluation, patients showed measurable increases in lip projection and definition following the recommended collagen-stimulating filler protocol:

+35% Lip volume restoration (Case A)
+19% Lip projection increase (Case B)
4–6 Sessions per anti-aging cycle
2 mo Maintenance interval
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Measured lip volume restoration: Case A — lip projection increased from 1.0 cm to 1.35 cm (+35%). Case B — from 1.6 cm to 1.9 cm (+19%). Results vary by patient anatomy and tissue aging degree.

View Full Clinical Data Results Gallery — All Skin Tones
Before and after case 1 CASE 01 · BEFORE / AFTER
Before and after case 2 with measurements CASE 02 · MEASURED
Before and after case 3 CASE 03 · BEFORE / AFTER
Before and after case 4 CASE 04 · BEFORE / AFTER
Treatment Protocol

Recommended Session Schedule

Based on degree of tissue aging, performed in 4–6 sessions at 20/30-day intervals, with maintenance every 2 months.

T0
Session 1 Baseline treatment
T20
Session 2 Day 20–30
T40
Session 3 Day 40–60
T60
Session 4–6 Continue cycle
T80
Maintenance Every 2 months
For Aesthetic Clinics · Distributors · OEM Brands

Lip Filler Wholesale & OEM Manufacturing

CEHISHU is a medical-grade dermal filler supplier serving licensed aesthetic clinics, lip filler distributors, and OEM brands across 40+ countries. As a medical-grade filler manufacturer, we provide full regulatory documentation, clinical training materials, and dedicated export account support.

Whether you're a clinic seeking lip filler wholesale pricing, a distributor looking for exclusive territory rights, or a brand exploring private label dermal filler manufacturing — we have a B2B partnership model to match.

40+ Export Countries
1,200+ Partner Clinics
15+ Exclusive Distributors
24h Response Time
Become a Partner OEM / ODM Services
Lip anatomy and injection plane

Superior & inferior labial artery distribution — anatomical reference for safe injection

Beyond CEHISHU

OEM / ODM Manufacturing

Leverage our formulation expertise and GMP facility to launch your own branded lip filler — built on the same B12 + HA platform.

01

Formulation Customization

Adjust HA concentration, B12 percentage, or develop a proprietary active blend tailored to your brand positioning.

02

Private Label Packaging

Custom syringe design, retail cartons, inserts, and multi-language labeling compliant with your target market.

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Regulatory Support

Documentation packages for CE, FDA 510(k), and regional registrations — we prepare the dossier, you own the brand.

Explore OEM Services

Request a CEHISHU Quote

For clinic wholesale pricing, distributor partnerships, sample requests, or OEM inquiries — our medical aesthetics export team is ready to assist.

Submit Inquiry
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