What are the ingredients in CEHISHU lip filler?

CEHISHU contains 20mg/ml hyaluronic acid with fractionated molecular weight (2600KD to 50KD) and 0.1% Vitamin B12 (900 pg/ml), stabilized mechanically under nitrogen pressure without chemical cross-linking agents.

How does Vitamin B12 work in CEHISHU lip filler?

Vitamin B12 (cobalamin) plays a role in DNA synthesis and acts as a cofactor in biochemical processes. In CEHISHU, B12 reduces inflammation, promotes healthy cell growth, accelerates tissue healing, and provides analgesic and anti-pruritic action at the injection site.

How long do CEHISHU lip filler results last?

The initial treatment cycle is 4-6 sessions at 20-30 day intervals. Maintenance sessions every 2 months optimize and prolong results. Clinical measurements documented lip projection increases from 1.0cm to 1.35cm (Case A, +35%) and 1.6cm to 1.9cm (Case B, +19%).

CEHISHU Lip Filler Gel — Product Detail | Science, Clinical Data, Protocol

The Clinical Context

Why the Lip Mucosa Needs Special Care

Vulnerability of Lip Tissue

The lip mucosa requires special protection because the lips are more exposed to climatic variations than any other part of the body — leading to dryness, sensitivity, and inflammation.

The resulting unpleasant sensations can worsen, leading to particularly chapped lips with small wounds that are sometimes very painful.

The CEHISHU Solution

A novel skin booster specifically designed for the lip mucosa and perioral region — restoring correct hydration of the extracellular matrix and improving cellular metabolism.

A gel with unique ingredients: a mixture rich in nano-encapsulated Vitamin B12, combined with a calibrated concentration of hyaluronic acid with fractionated molecular weight.

Star Ingredient

Vitamin B12 — Cobalamin

The ruby-red vitamin that powers CEHISHU's regenerative action.

What is it? Why is it critical?

Vitamin B12, also known as cobalamin (which gives it its characteristic ruby-red color), is a water-soluble vitamin. In the human body, it plays an integral role in DNA synthesis and acts as a cofactor in numerous biochemical processes.

It is also able to nourish and promote the repair of damaged nerve tissue, and accelerates the proliferation of granulation tissue and the regeneration of epithelial cells.

✓ Anti-inflammatory action — reduces inflammation and improves skin health and appearance
✓ DNA synthesis activity — promotes healthy cell growth, improving wrinkles and signs of aging
✓ Tissue healing acceleration — in-vivo testing confirms faster healing, stimulation of tissue regeneration, and collagen fiber repair
✓ Analgesic & anti-pruritic — provides comfort during and after treatment

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Deficiency matters: B12 deficiency is associated with acne, psoriasis, hyperpigmentation, atopic dermatitis, and vitiligo — evidence of its essential role in skin health.

Core Technology

Fractionated-Molecular-Weight HA

Stabilized mechanically — without chemical cross-linkers.

Linear HA Matrix, Stabilized Without Chemicals

To provide better hydration and, critically, a longer-lasting effect over time, we use only a mechanical process under nitrogen pressure to stabilize a blend of hyaluronic acid with different molecular weights — from 2600 KD down to 50 KD.

This yields a stable mixture with both hydrating and bio-restructuring capabilities, able to determine tissue volume without altering the tissue structure.

✓ No chemical cross-linking — lower risk of adverse reactions and nodules
✓ Nitrogen-pressure mechanical stabilization — preserves HA bioactivity
✓ Multi-layer hydration — high MW (2600 KD) for surface plumping, low MW (50 KD) for deep tissue penetration
✓ Bio-restructuring capability — supports the natural extracellular matrix

Hyaluronic Acid Concentration	20 mg/ml
Vitamin B12 Concentration	0.1% (900 pg/ml)
HA Molecular Weight Range	2600 KD – 50 KD (fractionated matrix)
Stabilization Method	Mechanical process under nitrogen pressure — no chemical cross-linking
Presentation	Pre-filled syringe, 1 ml
Indication Area	Lip mucosa and perioral region
Target Injection Plane	Dermal-submucosal plane
Storage	2–8°C, protect from light
Shelf Life	24 months unopened
Regulatory	CE-marked medical device

Anatomical Reference

Anatomy & Injection Plane

Safe injection requires precise understanding of labial vascular anatomy.

Labial Artery Distribution

The superior and inferior labial arteries define the safe injection planes for lip augmentation. Understanding their distribution pattern is essential for avoiding intravascular injection and ensuring optimal product placement.

CEHISHU is designed for injection into the dermal-submucosal plane, where the stabilized HA matrix provides volume and definition while the B12 component stimulates local tissue regeneration.

Reference: Cotofana S. et al. — "Distribution pattern of the superior and inferior labial arteries: implication for safe upper and lower lip augmentation surgery." Plast. Reconstr. Surg. 139:1075, 2017.

Injection plane cross-section reference

Clinical Evidence

Before & After — Clinical Results

Measurable volumetric improvement documented across multiple cases.

Measured Outcomes

Clinical evaluation showed measurable increases in lip projection and definition following the recommended protocol:

1.0 → 1.35 cm Case A · +35% projection

1.6 → 1.9 cm Case B · +19% projection

4–6 Sessions per cycle

20–30 d Interval between sessions

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Results vary by patient anatomy, tissue condition, and adherence to protocol. Individual results not guaranteed.

CASE 01

CASE 02 · MEASURED

CASE 03

CASE 04

Intended Use

CEHISHU Lip Filler Gel is intended for professional injection into the lip mucosa and perioral region by licensed medical practitioners trained in aesthetic injection techniques. The product restores hydration of the extracellular matrix, stimulates cellular metabolism via Vitamin B12, and provides volumetric definition through the stabilized HA matrix.

Recommended Technique

Inject into the dermal-submucosal plane, respecting labial vascular anatomy
Use of micro-cannula is recommended to minimize vascular risk
Massage gently post-injection to ensure even distribution
Apply cold compress if needed to reduce transient swelling

Session Protocol

Perform 4–6 sessions at 20–30 day intervals based on degree of tissue aging. Follow with maintenance sessions every 2 months to optimize and prolong results.

Contraindications

Hypersensitivity to hyaluronic acid or Vitamin B12
Active infection or inflammation at the injection site
Pregnancy or breastfeeding
Autoimmune disease in active phase
Patients under 18 years of age

Potential Adverse Effects

Transient and self-limiting: local edema, erythema, tenderness at injection site — typically resolving within 24–72 hours. As with any injection procedure, there is a rare risk of vascular compromise. Practitioners must be trained to recognize and manage such events.

Important Note

This product must be administered only by qualified medical professionals with appropriate training in aesthetic injection techniques and knowledge of facial vascular anatomy.

Storage Conditions

Store at 2–8°C (refrigerated) — do not freeze
Protect from light
Keep in original packaging until use
Do not use after the expiration date

Shipping & Cold Chain

CEHISHU ships with validated cold-chain packaging for international export. Temperature loggers are included in wholesale shipments to verify chain-of-custody integrity. Shelf life: 24 months unopened under correct storage.

Export Documentation

Each shipment includes: Certificate of Analysis, Certificate of Origin, CE declaration of conformity, and product information sheet in English. Additional language versions available on request for OEM partners.

Wholesale & Distribution

CEHISHU is available to licensed aesthetic clinics, medical distributors, and importers with appropriate medical device import authorization. Pricing is provided on request based on volume, territory, and partnership type.

Order Process

Submit inquiry via our contact form with your clinic/distributor details
Our export team responds within 24 hours with a tailored quotation
Verify import authorization and regulatory requirements for your market
Production lead time: 15–20 business days for standard orders
Cold-chain shipping via validated express courier

Partnership Tiers

We offer three partnership tiers: Clinic Wholesale (open), Regional Distributor (territory-based), and Exclusive Distributor (with volume commitments). Contact us to discuss the right model for your business.

CEHISHU Lip Filler Gel